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KMID : 1036020140030010021
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지질.동맥경화학회지
2014 Volume.3 No. 1 p.21 ~ p.28
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Cholesterol Lowering Effects of Low-dose Statins in Korean Patients
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Kwon Jee-Eun
Kim Young
Hyun Seong-Hyup
Won Ho-Youn
Shin Seung-Yong
Lee Kwang-Je
Kim Sang-Wook
Kim Tae-Ho
Kim Chee-Jeong
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Abstract
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Objective: The aim of this study is to compare cholesterol lowering effects of low dose 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in Korean patients.
Methods: A total of 909 consecutive patients were enrolled prospectively according to the criteria of National Cholesterol Education Program guidelines. Lipid profiles were obtained before and 2 months after statin therapy.
Results: Atorvastatin 10 mg (n=260), lovastatin 20 mg (n=145), pitavastatin 2 mg (n=80), pravastatin 20 mg (n=28), rosuvastatin 5 mg (n=145), and simvastatin 20 mg (n=208) reduced low density lipoprotein (LDL) cholesterol by -41.8±11.0%, -33.8±12.8%, -39.3±10.8%, -31.5±8.9%, -48.8±12.3%, and -42.8±13.5%, respectively. LDL cholesterol less than 130 mg/dL was achieved in 90.3%, 76.9%, 88.5%, 85.2%, 97.2%, and 94.2%, respectively. The reduction of LDL cholesterol by 30% or more was obtained in 84.4%, 60.7%, 81.6%, 63.0%, 93.0%, and 83.5%, respectively. LDL cholesterol less than 70 mg/dL or the reduction by 50% or more was observed in a small portion of patients and was variable according to the different types of statins.
Conclusions: A low dose statin was enough to manage dyslipidemia in most Korean patients with low to moderate risks and was even effective in a subpopulation of high risk patients.
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KEYWORD
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3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, Hypercholesterolemia, LDL Cholesterol
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